English Views: 2 Author: Site Editor Publish Time: 2021-09-18 Origin: Site
According to a study published in the journal Nutrition Research, taking natural dietary fiber glucomannan can improve the digestive health of people who eat fatty foods. Japanese researchers tested the effectiveness of dietary fiber in a rat model.
Researchers have previously discovered that eating lily bulbs (a food containing glucomannan) helps balance the intestinal flora and increase intestinal immunoglobulin A (IgA, an indicator of intestinal immune function), mucin (intestinal immune function) An indicator of barrier function) and colonic alkaline phosphatase (ALP) activity in rats on a high-fat diet.
It has been confirmed that small intestinal ALP has a protective effect in inflammatory diseases. However, little is known about the function of colonic ALP activity.
The researchers hypothesized that in a rat model of a high-fat diet, dietary glucomannan can increase colonic ALP activity and gene expression.
To test their hypothesis, they fed male Sprague-Dawley rats with 30% lard, with or without 4% high or low viscosity glucomannan (HGM or LGM) for two weeks.
HGM and LGM in the diet can significantly increase colonic ALP activity without changing the ALP activity in the small intestine.
The colonic expression of IAP-1, an ALP gene expressed in the entire intestine, was significantly higher in the HGM and LGM groups than in the control group.
The colonic expression of other ALP genes (ie Akp3 and Alpl) is not affected by HGM and LGM.
HGM and LGM in the diet will greatly increase the level of IgA, mucin and cecal organic acids (such as lactic acid, n-butyric acid and propionic acid) in the stool.
The researchers pointed out that colonic ALP corresponds to fecal IgA, mucin, and cecal organic acids.
The researchers concluded that dietary glucomannan can enhance colonic ALP activity through the up-regulation of IAP-1, thereby protecting intestinal epithelial homeostasis.
