English Views: 2 Author: Site Editor Publish Time: 2021-12-08 Origin: Site
Clinically, chenodeoxycholic acid can dissolve cholesterol stones, and the treatment effect is very good for cases with small cholesterol stones in the gallbladder and good gallbladder function.
Chenodeoxycholic acid can also treat bile pigment stones and mixed stones. Chenodeoxycholic acid is colorless needle-like crystals, tasteless and bitter. Almost insoluble in water, soluble in ethanol, glacial acetic acid, and slightly soluble in chloroform. It is extracted from bile. At present, chenodeoxycholic acid is one of the most widely used clinical drugs for the treatment of gallstones.
This product is extracted from bile and is currently one of the world's most used drugs for the treatment of gallstones. It is also a raw material for the synthesis of ursodeoxycholic acid (UDCA) and other steroidal compounds. It is mainly used for cholesterol gallstones. It also has a certain effect on bile pigment stones and mixed stones.
After most patients take CDCA (when CDCA accounts for 70% of bile salts in bile), lipids return to the state of micelles, and cholesterol is in an unsaturated state, which dissolves and falls off the cholesterol in the stones. Large doses of CDCA (10-15mg/kg per day) can inhibit the synthesis of cholesterol and increase the secretion of bile in patients with cholelithiasis, but the secretion of bile salts and phospholipids remains unchanged.
